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KMID : 0545119960060040292
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Journal of Microbiology and Biotechnology
1996 Volume.6 No. 4 p.292 ~ p.294
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Relationship between Two Tetracycline Resistance Plasmids of Staphylococcus aureus in Korea
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KIM, WOO-KOO
SHIN, CHUL-KYO/MOON, KYUNG-HO
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Abstract
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To investigate the relationship between two tetracycline resistance (Tc^r) plasmids, the 24.82-kb pKH1 and the 4.44-kb pKH6, of Staphylococcus aureus isolated in Korea, cloning of the 4570-bp HindⅢ fragment into pBluescript Ⅱ KS^+ after partial digestion of the Tc^r plasmids pKH1 with HindⅢ and sequence determination of that fragment were carried out. Analysis of the sequences revealed that the 4570-bp HindⅢ fragment contained a 4011-bp fragment of the small Tc^r plasmid pKH6 flanked by the partial sequences of IS431mec. It was concluded from the above result that the pKH1 was produced by integration of the partial sequence of the pKH6 into another plasmid via IS431mec.
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